ea0026p456 | Thyroid cancer | ECE2011
Huijbers A
, Plantinga T S
, Oosting M
, Joosten L A B
, Aben K K H
, Netea M G
, Hermus A R M M
, Netea-Maier R T
Background: Loss of autophagy protein ATG16L1 enhances endotoxin-induced interleukin 1β (IL1β) production. IL1β has been found to have antineoplastic effects in thyroid malignancies. We hypothesized that a missense polymorphism in ATG16L1 autophagy gene (Thr300Ala) results in changes in the function of the molecule and influences susceptibility to and prognosis of epithelial cell derived thyroid carcinoma (TC).Objective: i) To assess the f...